An air strike by the US-led coalition against ISIS has killed 25 people including children in the militant groups last enclave on the Euphrates in eastern Syria, the Syrian Observatory for Human Rights said on Monday. The air strike took place on Sunday in the settlement of Dahra Alouni close to al-Shaafa region, and more than half of those killed were women and children, said the Britain-based monitor. "Twenty-five civilians, including seven children, were killed in the village of Shaafa and in surrounding desert areas in coalition strikes all through Sunday," the head of the Observatory, Rami Abdel Rahman, said. Asked about the report, Coalition Cpokesman Colonel Ryan Dillon said: "We take all allegations seriously and as we always do we will put it into our civilian casualty assessment and we will publish the results of those on a monthly basis." ISIS has lost most of the territory it had captured in Syria in the face of military campaigns by both the US-led coalition that supports an alliance of Syrian fighters and by Syrian regime forces, which are backed by Russia and Iran. But the extremist group still holds small pockets of land in eastern Syria on both sides of the Euphrates, and also in a southern suburb of Damascus and in the countrys southwest. War monitors say coalition air strikes during the campaigns against ISIS in Syria and Iraq have killed large numbers of civilians. The coalition says it takes great care to avoid civilian casualties.