Israeli Prime Minister Benjamin Netanyahu vowed Wednesday to prevent Iran from entrenching itself in Syria as he visited Moscow for talks with President Vladimir Putin focusing on regional security. For Netanyahu, its the first trip to Moscow since Septembers downing of a Russian warplane by Syrian forces that were responding to an Israeli air strike. The incident left 15 Russian crew dead and threatened to derail close security ties between Russia and Israel, reported the Associated Press. Putin said at the start of Wednesdays talks that "its very important to discuss the situation in the region and security issues." He added that the high-level consultations are essential in view of the evolving situation. Netanyahu began the talks by reaffirming Israels strong determination to block attempts by Iran to establish a foothold in Syria. "The greatest threat to stability and security in the region comes from Iran and its satellites," he said. "We are determined to continue with our aggressive action against the efforts of Iran, which calls for our destruction, and against its attempts to entrench militarily in Syria." Moscow has played a delicate diplomatic game of maintaining friendly ties with both Israel and Iran. Last summer, Moscow struck a deal with Tehran to keep its fighters away from the Golan Heights to accommodate Israeli concerns about the Iranian presence in Syria. Netanyahu noted that he and Putin have had 11 meetings since September 2015 and hailed "the direct, open and true way in which we maintain the relationship between Russia and Israel." "The direct connection between us has been an essential element that has prevented risks and conflicts between our militaries, and that has contributed to regional security and stability," the Israeli leader said.