LONDON (Reuters) - English doctors are grappling with the prospect of seven-day service, -75 degree Celsius freezers and vaccines known as “Talent” and “Courageous” as they prepare for an unprecedented logistical challenge: the roll-out of COVID-19 vaccinations.Health minister Matt Hancock has set a target for England’s National Health Service that it should be ready to administer vaccines by Dec. 1, although he has said his central expectation is for the bulk of the roll-out to happen next year. Any distribution of vaccines would also require approval from the country’s medical watchdog, the MHRA. On Wednesday, NHS England medical director Stephen Powis confirmed that general practitioners (GPs), pharmacies and large-scale inoculation centres could all be involved in the vaccine roll-out, adding more details would be given in the coming days. “There’s going to be some nationally organised vaccine immunisation centres, which will be large centres, probably run with military involved, etc. But GPs are well placed,” Steve Mowle, a practising GP and honorary treasurer of the Royal College of General Practitioners, told Reuters. “The challenge of this task is even bigger than the flu immunisation programme. But I’m sure that GPs will have a very central role in delivering the COVID-19 vaccine.” Germany is scouting trade fair halls and airport terminals as possible mass vaccination centres, while Italy plans to lean on its existing GP network. But in many countries, details of how the population will be inoculated are scarce.