Investors stayed focused on updates about a handful of vaccine candidates and the start of global shipments as drugmakers submit paperwork for regulatory approvals. Pfizer Inc jumped almost 3% after the drugmaker and Germany’s BioNTech SE sought emergency approval of their vaccine candidate from the European regulator. The partners are neck-and-neck with rival Moderna Inc, which also applied for emergency approval from the European regulator. Its stock tumbled nearly 8% from a record high the day before. “There is this optimism about what it means as we see news around vaccines emerge,” said Bill Northey, senior investment director at U.S. Bank Wealth Management in Minneapolis. ADVERTISEMENT “As we look toward a health solution, we could be sitting on a coiled spring of economic activity, but it could take a while for it to be unleashed.” Earlier in the day, global equities got a boost from data that showed China’s factory activity in November increased at its fastest pace in a decade. Several other countries also reported sharp upticks in factory activity. U.S. data showed a recovery in manufacturing activity lost momentum in November. All 11 S&P 500 sector indexes rose, with communication services up 2% and the leading gains. FILE PHOTO: A small shopping basket filled with vials labeled "COVID-19 - Coronavirus Vaccine" and medical syringes are placed on a U.S. flag in this illustration taken November 29, 2020. REUTERS/Dado Ruvic/Ilustration In extended trade, Slack Technologies fell 1% after Salesforce.com Inc agreed to buy the messaging app company in a $28 billion deal. Salesforce fell 3.5%. On Tuesday, investors also focused on remarks by U.S. Treasury Secretary Steve Mnuchin and Federal Reserve Chair Jerome Powell at the Senate Banking Committee, where they agreed on the need for more aid for small businesses. Meanwhile, a bipartisan group of U.S. lawmakers unveiled a $908 billion COVID-19 relief bill aimed at breaking a months-long deadlock between Democrats and Republicans over new emergency assistance for small businesses, unemployed people, airlines and other industries during the pandemic. The Dow Jones Industrial Average rose 0.63% to end at 29,823.92 points, while the S&P 500 gained 1.13% to 3,662.44. The Nasdaq Composite climbed 1.28% to 12,355.11. All three main stock indexes gained more than 10% in November. Zoom Video Communications Inc slumped 15% after warning its gross margins would remain under pressure going into 2021. Tesla Inc rose 3% after S&P Dow Jones Indices said it would add one of Wall Street’s most valuable companies to the S&P 500 index in one go on Dec. 21, rather than in two tranches. Micron Technology Inc advanced 4.7% as the chipmaker increased its revenue, gross margin and earnings forecast for the first quarter. Advancing issues outnumbered declining ones on the NYSE by a 2.45-to-1 ratio; on Nasdaq, a 1.38-to-1 ratio favored advancers. The S&P 500 posted 48 new 52-week highs and no new lows; the Nasdaq Composite recorded 185 new highs and 8 new lows. Volume on U.S. exchanges was 13.5 billion shares, compared with the 11.5 billion average over the last 20 trading days. Additional reporting by Shriya Ramakrishnan and Medha Singh in Bengaluru; Editing by Richard Chang Our Standards: The Thomson Reuters Trust Principles.