May 11 (Reuters) - Wall Street’s main indexes opened sharply lower and the Nasdaq shed 2% on Tuesday, weighed down by technology-related stocks with lofty valuations on worries over inflation. The Nasdaq Composite dropped 286.0 points, or 2.13%, to 13115.854 at the opening bell. The Dow Jones Industrial Average fell 170.1 points, or 0.49%, at the open to 34,572.74 and the S&P 500 fell 38.1 points, or 0.91%, at the open to 4,150.34. (Reporting by Medha Singh in Bengaluru; Editing by Arun Koyyur) Our Standards: The Thomson Reuters Trust Principles.