Israel killed a Hamas commander and vowed no let-up in its Gaza barrages as Palestinian militants rained rockets far across the border, but U.S. President Joe Biden said he expected their fiercest hostilities in years might end soon. At least 65 people have been killed in Gaza since violence escalated on Monday, according to the enclave"s health ministry. Seven people have been killed in Israel, medical officials said. Israeli Prime Minister Benjamin Netanyahu said the Gaza City brigade commander was among the around 30 Gaza fighters that Israel believes it has killed in air strikes. "This is just the beginning. We"ll hit them like they"ve never dreamed possible," he said on Wednesday. After nightfall, Israeli strikes hit a Hamas-linked bank, as well as three roads in the enclave. Hamas confirmed the death of the commander and of "other leaders and holy warriors" in a statement. Its chief Ismail Haniyeh added: "The confrontation with the enemy is open-ended." Hamas and allied group Islamic Jihad fired rockets at the Tel Aviv area and the cities of Ashdod, Ashkelon and Sderot. Israel launched its offensive after Hamas fired rockets in retaliation for Israeli police clashes with Palestinians near al-Aqsa mosque in East Jerusalem during the fasting month of Ramadan. These escalated ahead of a court hearing - now postponed - that could lead to the eviction of Palestinian families from East Jerusalem homes claimed by Jewish settlers. Describing the scenes of destruction as "harrowing", U.S. Secretary of State Antony Blinken said a senior aide, Hady Amr, would be sent to urge Israelis and Palestinians to seek calm. "My expectation and hope is this will be closing down sooner than later, but Israel has a right to defend itself," Biden told reporters at the White House after speaking to Netanyahu. Biden did not explain the reasons behind his optimism. A Palestinian source said truce efforts by Egypt, Qatar and the United Nations had made no progress to end the violence. Hours earlier, Israel pledged to keep pummelling Hamas in what has been the heaviest fighting since a 2014 Gaza war. "A "truce" is not part of the jargon on our lips, certainly not in the coming day or two," military spokesman Brigadier-General Hidai Zilberman told public broadcaster Kan. The fighting has touched off strife within Israel, where some in the Arab minority mounted violent pro-Palestinian protests. Media reported spreading street attacks by Jews on Arab passersby in ethnically mixed areas on Wednesday. GAZA HIGH-RISES HIT In Gaza, two multi-storey residential buildings and a tower housing media outlets, including one linked to Hamas, collapsed after Israel urged occupants to evacuate in advance of its air strikes, and another structure was heavily damaged. "Israel has gone crazy," said a man on a Gaza street, where people ran out of their homes as explosions rocked buildings. The military said its strikes were targeting rocket launch sites, Hamas offices and the homes of Hamas leaders. Many in Israel also holed up in shelters as waves of rockets hit its heartland, some blown out of the sky by Iron Dome interceptors. "All of Israel is under attack. It"s a very scary situation to be in," said Margo Aronovic, a 26-year-old student, in Tel Aviv. Along the Gaza border, an Israeli soldier was killed by an anti-tank missile, the military said. Two people were killed by a rocket in Lod, a mixed Arab-Jewish town near Tel Aviv. After a synagogue was torched in Lod, police deployed paramilitary reinforcements and announced a curfew. read more In northern Acre, a Jewish motorist was beaten by Arab residents, and in Bat Yam, a Tel Aviv suburb, Jewish youths ransacked stores and beat an Arab, Israeli media reported. "We must not be dragged into provocations and inflicting harm on people or property," Chief Rabbi Yitzhak Yosef said in a rare public appeal. "The Torah of Israel grants no license for taking the law into one"s hands and acting violently." For Israel, the targeting of Tel Aviv, its commercial capital, posed a new challenge in the confrontation with Hamas, regarded as a terrorist group by Israel and the United States. GAS PLATFORM SHUT, FLIGHTS CANCELLED U.S. energy corporation Chevron said it had shut down the Tamar natural gas platform off the Israeli coast as a precaution. Israel said its energy needs would continue to be met. read more At least two U.S. airlines cancelled flights from the United States to Tel Aviv on Wednesday and Thursday. read more Israel, whose Ben Gurion Airport briefly suspended operations on Monday after a rocket barrage on Tel Aviv, said national airline El Al stood ready to provide supplemental flights. The conflict has led to the freezing of talks by Netanyahu"s opponents on forming a governing coalition to unseat him after Israel"s inconclusive March 23 election. Violence also flared in the occupied West Bank. Medical sources said a 16-year-old Palestinian was killed in clashes with Israeli forces on Wednesday. Another Palestinian was killed after wounding two people in a gun attack, the military said. Gaza"s health ministry said 16 of the people killed in the enclave were children. The Israeli military said on Thursday that some 350 of 1,500 rockets fired by Gaza factions had fallen short, potentially causing some Palestinian civilian casualties. Six of the fatalities in Israel were civilians, including two children and an Indian worker, medical officials said. Israel has dispatched infantry and armour to reinforce tanks already gathered on the border, evoking memories of its last ground incursion into Gaza to stop rocket attacks in 2014. Although the latest problems in Jerusalem were the immediate trigger for hostilities, Palestinians have been frustrated as their aspirations for an independent state have suffered setbacks in recent years. These include Washington"s recognition of disputed Jerusalem as Israel"s capital, a U.S. plan to end the conflict that they saw as favourable to Israel, and continued settlement building.