The Taliban on Saturday ruled out cooperation with the US to contain extremist groups in Afghanistan, staking out an uncompromising position on a key issue ahead of the first direct talks between the former foes since America withdrew from the country in August. Senior Taliban officials and US representatives are to meet Saturday and Sunday in Doha, Qatar. Officials from both sides have said issues include reining in extremist groups and the evacuation of foreign citizens and Afghans from the country. The Taliban have signaled flexibility on evacuations. Taliban political spokesman Suhail Shaheen told The Associated Press there would be no cooperation with Washington on going after the increasingly active ISIS group affiliate in Afghanistan. “We are able to tackle ISIS independently,” Shaheen said, when asked whether the Taliban would work with the US to contain the ISIS affiliate. The weekend meetings in Doha are the first since US forces withdrew from Afghanistan in late August, ending a 20-year military presence, and the Taliban rose to power in the nation. The US has made it clear the talks are not a preamble to recognition. The talks also come on the heels of two days of difficult discussions between Pakistani officials and US Deputy Secretary of State Wendy Sherman in Islamabad. The focus of those talks was also Afghanistan. Pakistani officials urged the US to engage with Afghanistans new rulers and release billions of dollars in international funds to stave off an economic meltdown. Pakistan also had a message for the Taliban, urging them to become more inclusive and pay attention to human rights and its minority ethnic and religious groups. Afghanistans Shiite clerics assailed the Taliban rulers following Fridays attack demanding greater protection at their places of worship. The ISIS affiliate claimed responsibility and identified the bomber as a Uygher Muslim. The claim said the attack targeted both Shiites and the Taliban for their purported willingness to expel Uyghers to meet demands from China. It was the deadliest attack since foreign troops left Afghanistan at the end of August. Michael Kugelman, deputy director of the Asia Program at the US-based Wilson Center, said Fridays attack could be a harbinger of more violence. Most of the Uyghur militants belong to the East Turkestan Islamic Movement, which has found a safe haven in the border regions of Pakistan and Afghanistan for decades. “If the ISIS claim is true, China’s concerns about terrorism in (Afghanistan)—to which the Taliban claims to be receptive—will increase,” he tweeted following the attack Both Afghanistan and Pakistan want the anticipated economic benefits from Chinas multi-billion Belt and Road initiative project linking Beijing to Central and South Asia. They have been willing to ignore Chinas persecution of its Muslim Uyghur population. Taliban spokesman Zabihullah Mujahid last month called the Chinese project the regions most important economic venture. During the Doha talks, US officials will also seek to hold Taliban leaders to commitments that they would allow Americans and other foreign nationals to leave Afghanistan, along with Afghans who once worked for the US military or government and other Afghan allies, a US official said. The official spoke on condition of anonymity because they were not authorized to speak on the record about the meetings. The Biden administration has fielded questions and complaints about the slow pace of US-facilitated evacuations from Taliban-ruled Afghanistan since the US withdrawal.