A coalition of 10 states sued the federal government on Wednesday to try to block a Covid-19 vaccine requirement for healthcare workers, marking a new front in the resistance by Republican-led states to the pandemic policies of President Joe Biden’s administration. The lawsuit filed in a federal court in Missouri contends that the vaccine requirement threatens the jobs of millions of healthcare workers and could “exacerbate an alarming shortage” in healthcare fields, particularly in rural areas where some health workers have been hesitant to get the shots. The suit follows similar ones by Republican-led states challenging new Biden administration rules that will require federal contractors to ensure their workers are vaccinated and that businesses with more than 100 employees require their workers to get vaccinated or wear masks and get tested weekly for the coronavirus. All of the mandates are scheduled to take effect on 4 January. Biden’s administration contends that the federal rules supersede state policies prohibiting vaccine mandates and are essential to slowing the pandemic, which has killed more than 755,000 people in the US. But the New Orleans-based fifth circuit court of appeals already has temporarily blocked the business vaccine rule, saying it raises “grave statutory and constitutional issues”. A separate rule issued last week by the federal Centers for Medicare & Medicaid Services requires Covid-19 vaccinations for more than 17 million workers in about 76,000 healthcare facilities and home healthcare providers that get funding from the government health programs. The new lawsuit contends that the CMS vaccine requirement is unprecedented and unreasonably broad, affecting even volunteers and staff who don’t typically work with patients. “The mandate is a blatant attempt to federalize public health issues involving vaccination that belong within the States’ police power,” said the suit filed by Missouri attorney general Eric Schmitt, a Republican who is running for US Senate. Joining the lawsuit were the attorneys general of Alaska, Arkansas, Iowa, Kansas, Nebraska, New Hampshire, North Dakota, South Dakota and Wyoming. All are Republicans except for Democratic Attorney General Tom Miller of Iowa, whose state is led by Republican governor Kim Reynolds. A CMS spokesperson declined to comment about the lawsuit. The lawsuit points to concerns from rural hospital administrators in Missouri and Nebraska. For example, it says that Great Plains Health in North Platte, Nebraska, is able to staff only about 70 of its 116 beds because of workforce shortages and has received notice from a majority of personnel in its behavioral health unit that they would resign rather than be vaccinated. Workplace vaccine mandates have become more common recently and generally have resulted in significant compliance. In New York City, more than 90% of city employees had received the vaccine before a 1 November mandate began. In the private sector, Tyson Foods told its 120,000 US workers that they must be vaccinated by 1 November. As of last week, the company said more than 96% of its workforce was vaccinated, including 60,500 people who got their shots after the August announcement.