Danish drugmaker Novo Nordisk (NOVOb.CO) has agreed a $3.3 billion cash deal to buy Dicerna Pharmaceuticals (DRNA.O) which specializes in therapeutics that counteract disease-causing genes, it said on Thursday. With the deal, Novo is following rivals including Novartis (NOVN.S) by betting on RNA interference technology, or RNAi, where genes that contribute to disease are silenced or rendered ineffective. Genes play a primary role in thousands of diseases. Novo started a research collaboration with Dicerna in 2019, pursuing several clinical candidates for disorders including chronic liver disease, non-alcoholic steatohepatitis (NASH), type 2 diabetes, obesity and rare diseases. "This acquisition supports Novo Nordisk"s strategy of developing and applying a broad range of technology platforms across all Novo Nordisk therapeutic areas," the company said in a statement. The deal for $38.25 per share represents a premium of 79.7% to the closing price on Wednesday for Dicerna, which is based in Lexington, Massachusetts. Novo, the world"s biggest producer of diabetes drugs, said it expects to initiate clinical development of the first investigational therapeutic to emerge from this collaboration in 2022. Novartis bought anti-cholesterol RNAi drug Leqvio, or inclisiran, in 2019 as part of its $9.7 billion takeover of The Medicines Co. The compound is approved for use in Europe but the U.S. clearance has been delayed. Other companies that work on RNAi cardiovascular drugs include Amgen (AMGN.O) with partner Arrowhead Pharmaceuticals (ARWR.O) as well as Regeneron (REGN.O) and partner Alnylam Pharmaceuticals (ALNY.O). Novo"s U.S.-listed shares traded 1.2% higher in premarket. Its Copenhagen-listed shares were up 0.5%, largely unchanged. The transaction, which will mainly be debt-financed, is expected to close in the fourth quarter of 2021. The acquisition will not impact Novo"s full-year guidance, but is estimated to have a negative impact on operating profit growth in 2022 of around 3%.