U.S. stock indexes were set to fall on Thursday after logging three straight days of gains on positive updates on the Omicron coronavirus variant, with focus now turning towards economic data for clues on the Federal Reserve"s policy decision. At 8:49 a.m. ET, Dow e-minis were down 0.39% at 35,605. S&P 500 e-minis were down 0.35% at 4,682.75 and Nasdaq 100 e-minis were down 0.38% at 16,329.75. ** American Airlines Group Inc (AAL.O): down 0.8% premarket BUZZ-To cut international flights citing Dreamliner delays, WSJ reports ** GameStop Corp (GME.N): down 5.1% premarket BUZZ-Falls after Q3 loss, subpoena disclosure, PT cuts ** Heron Therapeutics Inc (HRTX.O): up 4.9% premarket BUZZ-Rises as U.S. FDA approves expanded label for painkiller ** SPI Energy (SPI.O): up 6.9% premarket BUZZ-Rises as unit secures long-term supply deal ** Relmada Therapeutics (RLMD.O): down 4.2% premarket BUZZ-Prices upsized $150 mln equity offering ** EVgo Inc (EVGO.O): up 12.7% premarket BUZZ-Surges on PlugShare platform update, JPM "overweight" initiation ** Greenwich LifeSciences Inc (GLSI.O): up 1.6% premarket BUZZ-Up after cancer therapy trial data ** Zimmer Biomet Holdings Inc (ZBH.N): down 0.8% premarket BUZZ-Needham downgrades co over COVID-19 uncertainty ** Aurinia Pharmaceuticals Inc (AUPH.O): up 9.0% premarket BUZZ-Rises on positive drug data from late-stage continuation study ** Kinross Gold Corp : down 6.8% premarket BUZZ-Down on deal to buy Great Bear for $1.42 bln ** CVS Health Corp (CVS.N): up 2.6% premarket BUZZ-Rises on 2021 profit forecast raise, 2022 outlook ** PNM Resources (PNM.N): down 3.6% premarket BUZZ-Down as New Mexico regulators deny Avangrid bid for co ** Uber Technologies Inc (UBER.N): down 0.9% premarket Grab Holdings Limited : down 1.2% premarket Lyft Inc (LYFT.O): down 1.4% premarket BUZZ-Food delivery firms, ride hailing cos hit by EU"s draft of gig labor rules ** Torrid Holdings Inc (CURV.N): down 25.4% premarket BUZZ-Down on Q3 revenue miss, weak forecast ** Reata Pharmaceuticals (RETA.O): down 40.1% premarket BUZZ-Eyes over 3-year low on U.S. FDA decision ** Agree Realty Corp (ADC.N): down 3.6% premarket BUZZ-Drops on pricing share offering at discount ** Altice USA Inc (ATUS.N): down 2.0% premarket BUZZ-Falls after J.P. Morgan downgrades to "neutral" Compiled by Manya Saini in Bengaluru Our Standards: The Thomson Reuters Trust Principles.