A heartfelt Patti LaBelle praised her lifelong friend Gladys Knight. Sean Penn called U2 "four scrappy Dublin punks." Ballet dancers performed for conductor and composer Tania León. Matt Damon playfully teased his friend George Clooney — a lot — while Sheryl Crow delivered a heartfelt rendition of "Baby Baby" to Amy Grant during Sundays Kennedy Center Honors.  Knight, Clooney, Grant, León and U2 were all celebrated at the John F. Kennedy Center for the Performing Arts, which annually honors a select group of people for their artistic influences on American culture. President Joe Biden, Vice President Kamala Harris and their spouses attended, as did members of the presidents Cabinet and Congress.  One audience member from the political world — Paul Pelosi, husband of House Speaker Nancy Pelosi — drew some attention. He is recovering from a brutal attack in the Pelosis’ San Francisco home in October. The couple received a standing ovation.  Normally performers like U2 or Knight would be headlining such a show, but during the Kennedy Center event the honorees sit in the balcony and watch as their peers laud them and perform their works.  On the red carpet, Clooney, with his wife, Amal, beside him, joked that after seeing friends like Don Cheadle and Julia Roberts in attendance, he was worried his tribute would be more of a "roast." And it was a bit like that, though his friends and family showed obvious respect.  Roberts set the tone by coming onstage with a dress emblazoned with photos of Clooney. After an introduction that alternated between funny and heartfelt, she turned to a set designed to look like a smoky bar — the type Clooney might enjoy. The actors father, Nick Clooney, told stories of a young George, including the time the 7-year-old — heartbroken over the assassination of Martin Luther King Jr. in 1968 — gave his father all his toy guns.  Damon took the funny road, joking about how Clooney once stole then-President Bill Clintons stationery and wrote notes to fellow actors on it. Cheadle highlighted Clooneys philanthropic work. But it was Clooneys father who probably had the strongest praise, telling the crowd and his son, sitting in the balcony between León and U2s Bono, "Georges best and most important work is still ahead of him."  Standing on a stage lit by a massive sign reading "Gladys," LaBelle called Knight her "everything," saying they had been friends for six decades and had seen each other through laughter and tears. "We do everything together," LaBelle said. "I am honored to honor you tonight."  Actor and hip-hop star LL Cool J said that whenever Knight sings she connects with people. "I once heard Gladys sing the ABCs and I thought I was in church," he said.  Knight — usually with her backup singers, The Pips — has recorded dozens of albums with such classic hits as "I Heard It Through the Grapevine" and "Midnight Train to Georgia." The challenge of singing that classic in front of the woman who made it famous fell to country music superstar Garth Brooks, who is a Kennedy Center honoree in his own right. He cited Knight’s "roots in country music" before launching into the classic.  Five ballet dancers took to the stage to honor León, who left Cuba as a refugee in 1967; her passport was stamped "Cancelado" when she left the country. The performers were from the Dance Theatre of Harlem, which León helped found when she eventually made her way to New York City. She also instituted the Brooklyn Philharmonic Community Concert Series and in 2021 received the Pulitzer Prize for her work "Stride," inspired by womens rights champion Susan B. Anthony.  "How do I convey the extent of your musical genius?" asked actress and playwright Anna Deavere Smith. Jazz pianist Jason Moran, singer Alicia Hall Moran and cellist Sterling Elliott played one of Leóns creations, "Oh Yemanja."  The last honoree of the night was U2. In a videotaped Saturday, U2 guitarist The Edge noted that a group of four "Irish lads" were being honored for contributions to American culture and said theres a bond between the group and America that cant really be explained.  Pearl Jams Eddie Vedder sang U2s "Elevation" and "One." Comedian Sacha Baron Cohen brought his alter ego Borat to the stage as part of the U2 tribute, pretending to mistake Biden for former President Donald Trump. Singers Brandi Carlile, Hozier and Jamala — from the US, Ireland and Ukraine, respectively — closed out the show with an emotional version of "Walk On."  U2s Bono is also known for his philanthropic work to eradicate poverty and to raise awareness about AIDS. Jamala, whose home country of Ukraine has been embroiled in nearly a year of bloody warfare after the Russian invasion, touched on that history of social activism as she introduced the nights final song.  "Its fitting that on the night meant to honor them they have once again used their platform to spread a message of peace," she said. "Honestly to be here in this bright warm hall this evening is really something extraordinary for me, when there is so much darkness in my home country Ukraine."  The honorees came to the theater from a White House reception where Biden praised them before a star-studded East Room crowd as an "exceptional group of artists."  "Thank you for showing us the power of the arts and ‘We the People,’" Biden said.