A Palestinian militant group said three of its leaders were killed in an Israeli attack on central Beirut early on Monday, in what would be the first time Israel’s military had struck the centre of Lebanon’s capital city since 2006, as it expanded hostilities against Iran’s regional allies with further attacks across Lebanon and Yemen. The Popular Front for the Liberation of Palestine (PFLP), a militant group taking part in the fight against Israel, said three senior figures were killed in the Beirut attack, with initial footage from the scene showing two storeys of an apartment building completely blown out, and onlookers running towards the building. Two bodies could be seen lying on the street atop a car outside the building, seemingly ejected by the force of the blast. The sound of the explosion was heard around the city. There was no immediate comment from Israel’s military. The Beirut strike, carried out using a drone, according to one source quoted by Agence France-Presse, hit near the Kola intersection, a popular reference point in the city, where taxis and buses gather to pick up passengers. Israel had confined its strikes on Lebanon’s capital city to its southern suburbs. The airstrike threw into doubt which areas of Beirut were still safe from Israel’s expanding aerial campaign. Israeli drones hovered over Beirut for much of Sunday, with the loud blasts of new airstrikes echoing around the city. Monday’s airstrike comes after Lebanon’s health ministry said 105 people had been killed and another 359 injured by Israeli strikes across the country on Sunday. More than 1,000 Lebanese have been killed and 6,000 wounded in the past two weeks, it said, without saying how many were civilians. The government said a million people – a fifth of the population – have fled their homes. On Sunday, Israel launched a wave of airstrikes against Houthi targets in Yemen, fuelling fears of a slide towards a devastating regional conflict on multiple fronts. The attack on the port of Hodeidah in Yemen involved dozens of Israeli planes and appears to have targeted fuel facilities, power plants and docks at the Ras Issa and Hodeidah ports. It one of the biggest such operations yet seen in the near year-long crisis in the region. Houthi media reported the strikes had killed four people and wounded 33. Residents said the strikes caused power cuts in most parts of Hodeidah. Israeli military officials said the raid targeted the Houthis, who have fired at Israeli targets for months in what they say is solidarity with Palestinians in Gaza. The Houthis have also targeted international shipping in the Red Sea. On Saturday, they launched a ballistic missile attack on Israel’s main international airport when Benjamin Netanyahu, the Israeli prime minister, was arriving. In Lebanon, Hezbollah confirmed that Nabil Kaouk, the deputy head of its central council, was killed on Saturday, making him the seventh senior Hezbollah leader slain in Israeli strikes in a little over a week. The group also confirmed that Ali Karaki, another senior commander, died in the airstrike on Friday that killed Hezbollah leader Hassan Nasrallah. Three days of mourning were announced, starting on Monday, after the killing of Nasrallah. Hezbollah denied claims that Abu Ali Rida, the commander of the group’s Bader Unit in south Lebanon had been killed. Rida is the last remaining senior military commander of Hezbollah who remains alive. Israel has vowed to keep up the assault and says it wants to make its northern areas secure again for residents who have been forced to flee Hezbollah rocket attacks. US president Joe Biden, asked if an all-out war in the Middle East could be avoided, said “It has to be.” He said he will be talking to Netanyahu.