Media mogul Oprah Winfrey has brushed off speculation she might run for US president in 2020, saying she lacks "the DNA for it." When Winfrey, 63, delivered a rousing speech at the Golden Globe Awards earlier this month it rekindled longstanding speculation over the billionaires political ambitions -- and a possible run for the Oval Office. But in an interview with InStyle, carried out three weeks before the Globes and published in the fashion magazines March issue, she downplayed the idea of a presidential run, saying: "Thats not for me." "Ive always felt very secure and confident with myself in knowing what I could do and what I could not," said the self-made entertainment tycoon. "And so its not something that interests me. I dont have the DNA for it," she added. It was unclear whether the enthusiastic response to her Globes speech -- after which anonymous friends of the chat show queen were reported as saying she was "actively thinking" about a 2020 run -- may have brought a change of heart. Winfrey went on in the interview to voice optimism about the current political US political climate. "I think whats exciting is this moment in our political history, in our social engagement," she said. "Its really opened a lot of people to the fact that they have a voice, and its gotten people involved in ways that they never wouldve been before." Winfrey, long associated with Democratic Party causes and fundraising, could not be reached for immediate comment. Known by millions on first-name basis, Winfrey first rose to fame as the host of a television talk show, using it to build a media empire that spans magazine publishing, movie and television production, cable TV and satellite radio. President Donald Trump relished the idea of a celebrity-versus-celebrity campaign, telling reporters earlier this month he did not think Winfrey would run but believed he would win that matchup. "Ill beat Oprah," Trump said. "Oprah would be a lot of fun."