Israel struck a dozen Syrian and Iranian targets inside Syria on Saturday after an Israeli fighter jet crashed under fire from Syrian air defenses, the military said. Israels raids came after it intercepted what it said was an Iranian drone that infiltrated its airspace from Syria. It marked the first time Israel publicly acknowledged attacking what it identified as Iranian targets in Syria since the war began in 2011. The Israeli military issued a warning to Tehran, saying it was responsible for the drone that entered Israel, which it labeled an "attack." It said its reprisals after the exchange were "large-scale" raids. Israeli aircraft “targeted the Syrian Aerial Defense System and Iranian targets in Syria," a military statement said. "Twelve targets, including three aerial defense batteries and four Iranian targets that are part of Irans military establishment in Syria were attacked." During the attack, anti-aircraft missiles were fired toward Israel jets triggering sirens that were sounded across northern Israel. Israel has repeatedly warned in recent weeks against the presence of Iranian forces in neighboring Syria. The Israeli pilots of the crashed F16 were reported alive, although one was severely wounded. Israels military called the drone infiltration a "severe and irregular violation of Israeli sovereignty" and said Iran would be held responsible for its outcome. "This is a serious Iranian attack on Israeli territory. Iran is dragging the region into an adventure in which it doesnt know how it will end," Israels chief military spokesman, Brig. Gen. Ronen Manelis, said in a special statement. "Whoever is responsible for this incident is the one who will pay the price."